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Partial agonist activity of α(1)-adrenergic receptor antagonists for chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3

We observed in PRESTO-Tango β-arrestin recruitment assays that the α(1)-adrenergic receptor (AR) antagonist prazosin activates chemokine (C-X-C motif) receptor (CXCR)4. This prompted us to further examine this unexpected pharmacological behavior. We screened a panel of 14 α(1/2)- and β(1/2/3)-AR ant...

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書目詳細資料
發表在:PLoS One
Main Authors: Gao, Xianlong, Abdelkarim, Hazem, Albee, Lauren J., Volkman, Brian F., Gaponenko, Vadim, Majetschak, Matthias
格式: Artigo
語言:Inglês
出版: Public Library of Science 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152952/
https://ncbi.nlm.nih.gov/pubmed/30248140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204041
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