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Partial agonist activity of α(1)-adrenergic receptor antagonists for chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3
We observed in PRESTO-Tango β-arrestin recruitment assays that the α(1)-adrenergic receptor (AR) antagonist prazosin activates chemokine (C-X-C motif) receptor (CXCR)4. This prompted us to further examine this unexpected pharmacological behavior. We screened a panel of 14 α(1/2)- and β(1/2/3)-AR ant...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6152952/ https://ncbi.nlm.nih.gov/pubmed/30248140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204041 |
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