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Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stability

The cytoplasmic abundance of mRNAs is strictly controlled through a balance of production and degradation. Whereas the control of mRNA synthesis through transcription has been well characterized, less is known about the regulation of mRNA turnover, and a consensus model explaining the wide variation...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Chan, Leon Y, Mugler, Christopher F, Heinrich, Stephanie, Vallotton, Pascal, Weis, Karsten
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152797/
https://ncbi.nlm.nih.gov/pubmed/30192227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32536
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