Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo

VCP/p97 (valosin containing protein) is a key regulator of cellular proteostasis. It orchestrates protein turnover and quality control in vivo, processes fundamental for proper cell function. In humans, mutations in VCP lead to severe myo- and neuro-degenerative disorders such as inclusion body myop...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Kustermann, Monika, Manta, Linda, Paone, Christoph, Kustermann, Jochen, Lausser, Ludwig, Wiesner, Cora, Eichinger, Ludwig, Clemen, Christoph S., Schröder, Rolf, Kestler, Hans A., Sandri, Marco, Rottbauer, Wolfgang, Just, Steffen
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper - Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152520/
https://ncbi.nlm.nih.gov/pubmed/30010465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1491491
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