ASC acts in a caspase-1-independent manner to worsen acute pneumonia caused by Pseudomonas aeruginosa

Purpose. Pseudomonas aeruginosa expresses a type III secretion system (T3SS) that activates the host inflammasome-mediated immune response. We examined the role of inflammasome activation in severe infection outcomes. Methods. We infected C57BL/6 (B6) mice lacking inflammasome components ASC or casp...

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Bibliographic Details
Published in:J Med Microbiol
Main Authors: Hughes, A. J., Knoten, C. A., Morris, A. R., Hauser, A. R.
Format: Artigo
Language:Inglês
Published: Microbiology Society 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152396/
https://ncbi.nlm.nih.gov/pubmed/29957172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jmm.0.000782
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