Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA

Musashi-1 (Msi1) controls the maintenance of stem cells and tumorigenesis through binding to its target mRNAs and subsequent translational regulation. Msi1 has two RNA-binding domains (RBDs), RBD1 and RBD2, which recognize r(GUAG) and r(UAG), respectively. These minimal recognition sequences are con...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Iwaoka, Ryo, Nagata, Takashi, Tsuda, Kengo, Imai, Takao, Okano, Hideyuki, Kobayashi, Naohiro, Katahira, Masato
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152312/
https://ncbi.nlm.nih.gov/pubmed/28753936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22071207
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