Identification of Novel Bisbenzimidazole Derivatives as Anticancer Vacuolar (H(+))-ATPase Inhibitors †

The vacuolar (H(+))-ATPases (V-ATPases) are a family of ATP-driven proton pumps and they have been associated with cancer invasion, metastasis, and drug resistance. Despite the clear involvement of V-ATPases in cancer, the therapeutic use of V-ATPase-targeting small molecules has not reached human c...

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Veröffentlicht in:Molecules
Hauptverfasser: Patil, Renukadevi, Kulshrestha, Arpita, Tikoo, Anjali, Fleetwood, Sara, Katara, Gajendra, Kolli, Bala, Seibel, William, Gilman-Sachs, Alice, Patil, Shivaputra A., Beaman, Kenneth D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151825/
https://ncbi.nlm.nih.gov/pubmed/28926955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22091559
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