Cargando...

Why is Aged Acetylcholinesterase So Difficult to Reactivate?

Organophosphorus agents are potent inhibitors of acetylcholinesterase. Inhibition involves successive chemical events. The first is phosphylation of the active site serine to produce a neutral adduct, which is a close structural analog of the acylation transition state. This adduct is unreactive tow...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Molecules
Main Authors: Quinn, Daniel M., Topczewski, Joseph, Yasapala, Nilanthi, Lodge, Alexander
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2017
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151809/
https://ncbi.nlm.nih.gov/pubmed/28869561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22091464
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!