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Why is Aged Acetylcholinesterase So Difficult to Reactivate?
Organophosphorus agents are potent inhibitors of acetylcholinesterase. Inhibition involves successive chemical events. The first is phosphylation of the active site serine to produce a neutral adduct, which is a close structural analog of the acylation transition state. This adduct is unreactive tow...
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| Veröffentlicht in: | Molecules |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6151809/ https://ncbi.nlm.nih.gov/pubmed/28869561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22091464 |
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