Discovery of Novel N-Substituted Prolinamido Indazoles as Potent Rho Kinase Inhibitors and Vasorelaxation Agents

Inhibitors of Rho kinase (ROCK) have potential therapeutic applicability in a wide range of diseases, such as hypertension, stroke, asthma and glaucoma. In a previous article, we described the lead discovery of DL0805, a new ROCK I inhibitor, showing potent inhibitory activity (IC(50) 6.7 μM). Herei...

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Vydáno v:Molecules
Hlavní autoři: Yao, Yangyang, Li, Renze, Liu, Xiaoyu, Yang, Feilong, Yang, Ying, Li, Xiaoyu, Shi, Xiang, Yuan, Tianyi, Fang, Lianhua, Du, Guanhua, Jiao, Xiaozhen, Xie, Ping
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151428/
https://ncbi.nlm.nih.gov/pubmed/29048389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22101766
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