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Discovery of Novel and Orally Bioavailable Inhibitors of PI3 Kinase Based on Indazole Substituted Morpholino-Triazines
[Image: see text] A new class of potent PI3Kα inhibitors is identified based on aryl substituted morpholino-triazine scaffold. The identified compounds showed not only a high level of enzymatic and cellular potency in nanomolar range but also high oral bioavailability. The three lead molecules (base...
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Publicado no: | ACS Med Chem Lett |
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Main Authors: | , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Chemical
Society
2015
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4677375/ https://ncbi.nlm.nih.gov/pubmed/26713102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00322 |
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