Discovery of Novel and Orally Bioavailable Inhibitors of PI3 Kinase Based on Indazole Substituted Morpholino-Triazines

[Image: see text] A new class of potent PI3Kα inhibitors is identified based on aryl substituted morpholino-triazine scaffold. The identified compounds showed not only a high level of enzymatic and cellular potency in nanomolar range but also high oral bioavailability. The three lead molecules (base...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Dugar, Sundeep, Hollinger, Frank P., Mahajan, Dinesh, Sen, Somdutta, Kuila, Bilash, Arora, Reena, Pawar, Yogesh, Shinde, Vaibhav, Rahinj, Mahesh, Kapoor, Kamal K., Bhumkar, Rahul, Rai, Santosh, Kulkarni, Rakesh
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2015
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677375/
https://ncbi.nlm.nih.gov/pubmed/26713102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00322
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