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Structural insights of a PI3K/mTOR dual inhibitor with the morpholino-triazine scaffold
Stimulation of the PI3K/Akt/mTOR pathway, which controls cell proliferation and growth, is often observed in cancer cell. Inhibiting both PI3K and mTOR in this pathway can switch off Akt activation and hence, plays a powerful role for modulating this pathway. PKI-587, a drug containing the structure...
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| Publicado no: | J Comput Aided Mol Des |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4833818/ https://ncbi.nlm.nih.gov/pubmed/26956874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-016-9905-4 |
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