Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway Pseudomonas aeruginosa Infection in Mice

Pseudomonas aeruginosa is a cause of high mortality in burn, immunocompromised, and surgery patients. High incidence of antibiotic resistance in this pathogen makes the existent therapy inefficient. Type three secretion system (T3SS) is a leading virulence system of P. aeruginosa that actively suppr...

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Publicat a:Biomed Res Int
Autors principals: Sheremet, Anna B., Zigangirova, Naylia A., Zayakin, Egor S., Luyksaar, Sergei I., Kapotina, Lydia N., Nesterenko, Ludmila N., Kobets, Natalie V., Gintsburg, Alexander L.
Format: Artigo
Idioma:Inglês
Publicat: Hindawi 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151375/
https://ncbi.nlm.nih.gov/pubmed/30276212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/5810767
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