The use of structural alerts to avoid the toxicity of pharmaceuticals

In order to identify compounds with potential toxicity problems, particular attention is paid to structural alerts, which are high chemical reactivity molecular fragments or fragments that can be transformed via bioactivation by human enzymes into fragments with high chemical reactivity. The concept...

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Bibliografiske detaljer
Udgivet i:Toxicol Rep
Main Authors: Limban, Carmen, Nuţă, Diana C., Chiriţă, Cornel, Negreș, Simona, Arsene, Andreea L., Goumenou, Marina, Karakitsios, Spyros P., Tsatsakis, Aristidis M., Sarigiannis, Dimosthenis A.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151358/
https://ncbi.nlm.nih.gov/pubmed/30258789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxrep.2018.08.017
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