Haem oxygenase‐1 up‐regulation by rosiglitazone via ROS‐dependent Nrf2‐antioxidant response elements axis or PPARγ attenuates LPS‐mediated lung inflammation

BACKGROUND AND PURPOSE: Haem oxygenase‐1 (HO‐1) is induced by thiazolidinediones including rosiglitazone and exerts anti‐inflammatory effects in various models. However, the molecular mechanisms underlying rosiglitazone‐induced HO‐1 expression remain largely unknown in human pulmonary alveolar epith...

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Detalles Bibliográficos
Publicado en:Br J Pharmacol
Main Authors: Cho, Rou‐Ling, Yang, Chien‐Chung, Tseng, Hui‐Ching, Hsiao, Li‐Der, Lin, Chih‐Chung, Yang, Chuen‐Mao
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151343/
https://ncbi.nlm.nih.gov/pubmed/30088830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14465
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