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17β‐Estradiol reduces mitochondrial cAMP content and cytochrome oxidase activity in a phosphodiesterase 2‐dependent manner

BACKGROUND AND PURPOSE: Mitochondria possess their own source of cAMP, that is, soluble adenylyl cyclase (sAC). Activation or expression of mitochondrial sAC promotes mitochondrial function. Oestrogen receptor signalling plays an essential role in the regulation of mitochondrial function. Here we ai...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Pozdniakova, Sofya, Guitart‐Mampel, Mariona, Garrabou, Gloria, Di Benedetto, Giulietta, Ladilov, Yury, Regitz‐Zagrosek, Vera
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151328/
https://ncbi.nlm.nih.gov/pubmed/30051530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14455
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