Polymorphisms in Cytochrome P450 are associated with Extensive Efavirenz Pharmacokinetics and CNS Toxicities in an HIV Cohort in Botswana

Inter-individual variability in efavirenz (EFV) pharmacokinetics and dynamics are dominantly driven by the polymorphism in cytochrome P450 (CYP) isoenzyme 2B6 516G>T. We hypothesized that additional CYP polymorphisms mediate the relationship between CYP2B6 516G>T, EFV metabolism, and clinical...

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Gepubliceerd in:Pharmacogenomics J
Hoofdauteurs: Vujkovic, Marijana, Bellamy, Scarlett L., Zuppa, Athena F., Gastonguay, Marc R., Moorthy, Ganesh S, Ratshaa, Bakgaki, Han, Xiaoyan, Steenhoff, Andrew P., Mosepele, Mosepele, Strom, Brian L., Bisson, Gregory P., Aplenc, Richard, Gross, Robert
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151142/
https://ncbi.nlm.nih.gov/pubmed/29855606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41397-018-0028-2
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