The phosphatidylinositide 3-kinase (PI3K) signaling pathway is a determinant of zileuton response in adults with asthma

Variable responsiveness to zileuton, a leukotriene antagonist used to treat asthma, may be due in part to genetic variation. While individual SNPs were previously associated with zileuton-related lung function changes, specific quantitative trait loci (QTLs) and biological pathways that may contribu...

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Vydáno v:Pharmacogenomics J
Hlavní autoři: Dahlin, Amber, Qiu, Weiliang, Litonjua, Augusto A., Lima, John J., Tamari, Mayumi, Kubo, Michiaki, Irvin, Charles G., Peters, Stephen P., Wu, Ann C., Weiss, Scott T., Tantisira, Kelan G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150906/
https://ncbi.nlm.nih.gov/pubmed/29298996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41397-017-0006-0
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