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Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors

A novel series of 2-substituted-4,6-diarylpyrimidines 6a–6t has been synthesized, characterized by (1)H-NMR, (13)C-NMR and HRMS, and screened for in vitro α-glucosidase inhibitory activity. The majority of the screened compounds possessed significant α-glucosidase inhibitory activity with IC(50) val...

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Bibliografiske detaljer
Udgivet i:Molecules
Main Authors: Gong, Zipeng, Xie, Zhenzhen, Qiu, Jie, Wang, Guangcheng
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150375/
https://ncbi.nlm.nih.gov/pubmed/29084182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22111865
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