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Zinc Ion-Dependent Peptide Nucleic Acid-Based Artificial Enzyme that Cleaves RNA—Bulge Size and Sequence Dependence

In this report, we investigate the efficiency and selectivity of a Zn(2+)-dependent peptide nucleic acid-based artificial ribonuclease (PNAzyme) that cleaves RNA target sequences. The target RNAs are varied to form different sizes (3 and 4 nucleotides, nt) and sequences in the bulge formed upon bind...

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Bibliographic Details
Published in:Molecules
Main Authors: Murtola, Merita, Ghidini, Alice, Virta, Pasi, Strömberg, Roger
Format: Artigo
Language:Inglês
Published: MDPI 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150328/
https://ncbi.nlm.nih.gov/pubmed/29109368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22111856
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