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Zinc Ion-Dependent Peptide Nucleic Acid-Based Artificial Enzyme that Cleaves RNA—Bulge Size and Sequence Dependence
In this report, we investigate the efficiency and selectivity of a Zn(2+)-dependent peptide nucleic acid-based artificial ribonuclease (PNAzyme) that cleaves RNA target sequences. The target RNAs are varied to form different sizes (3 and 4 nucleotides, nt) and sequences in the bulge formed upon bind...
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| Published in: | Molecules |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
MDPI
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6150328/ https://ncbi.nlm.nih.gov/pubmed/29109368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22111856 |
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