Sequence-specific RNA cleavage by PNA conjugates of the metal-free artificial ribonuclease tris(2-aminobenzimidazole)

Tris(2-aminobenzimidazole) conjugates with antisense oligonucleotides are effective site-specific RNA cleavers. Their mechanism of action is independent of metal ions. Here we investigate conjugates with peptide nucleic acids (PNA). RNA degradation occurs with similar rates and substrate specificiti...

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Publicado en:Beilstein J Org Chem
Main Authors: Danneberg, Friederike, Ghidini, Alice, Dogandzhiyski, Plamena, Kalden, Elisabeth, Strömberg, Roger, Göbel, Michael W
Formato: Artigo
Idioma:Inglês
Publicado: Beilstein-Institut 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419560/
https://ncbi.nlm.nih.gov/pubmed/25977723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.11.55
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