BCL‐2 levels do not predict azathioprine treatment response in inflammatory bowel disease, but inhibition induces lymphocyte apoptosis and ameliorates colitis in mice

In inflammatory bowel disease (IBD), inflammation is sustained by an exaggerated response of lymphocytes. This results from enhanced expression of anti‐apoptotic B cell lymphoma (BCL‐2) and BCL‐XL associated with a diminished turnover. Azathioprine (AZA) directly targets BCL‐2 family‐mediated apopto...

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Detalhes bibliográficos
Publicado no:Clin Exp Immunol
Main Authors: Weder, B., Mozaffari, M., Biedermann, L., Mamie, C., Moncsek, A., Wang, L., Clarke, S. H., Rogler, G., McRae, B. L., Graff, C. L., Ruiz, P. A., Hausmann, M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150252/
https://ncbi.nlm.nih.gov/pubmed/29745420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.13151
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