Increased lymphocyte apoptosis in mouse models of colitis upon ABT-737 treatment is dependent upon BIM expression

Exaggerated activation of lymphocytes contributes to the pathogenesis of inflammatory bowel disease (IBD). Medical therapies are linked to the BCL-2 family-mediated apoptosis. Imbalance in BCL-2 family proteins may cause failure in therapeutic responses. We investigated the role of BCL-2 inhibitor A...

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Detalhes bibliográficos
Publicado no:Clin Exp Immunol
Main Authors: Lutz, C, Mozaffari, M, Tosevski, V, Caj, M, Cippà, P, McRae, B L, Graff, C L, Rogler, G, Fried, M, Hausmann, M
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Translational
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516450/
https://ncbi.nlm.nih.gov/pubmed/25845418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12635
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