Modulation of Cytochrome P450, P-glycoprotein and Pregnane X Receptor by Selected Antimalarial Herbs—Implication for Herb-Drug Interaction

Seven medicinal plants popularly used for treating malaria in West Africa were selected to assess herb-drug interaction potential through a series of in vitro methods. Fluorescent cytochrome P450 (CYP) assays were conducted using the recombinant CYP enzymes for CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C1...

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Bibliographic Details
Published in:Molecules
Main Authors: Fasinu, Pius S., Manda, Vamshi K., Dale, Olivia R., Egiebor, Nosa O., Walker, Larry A., Khan, Shabana I.
Format: Artigo
Language:Inglês
Published: MDPI 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150001/
https://ncbi.nlm.nih.gov/pubmed/29168799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22122049
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