Species-Specific Inactivation of Triosephosphate Isomerase from Trypanosoma brucei: Kinetic and Molecular Dynamics Studies

Human African Trypanosomiasis (HAT), a disease that provokes 2184 new cases a year in Sub-Saharan Africa, is caused by Trypanosoma brucei. Current treatments are limited, highly toxic, and parasite strains resistant to them are emerging. Therefore, there is an urgency to find new drugs against HAT....

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Pubblicato in:Molecules
Autori principali: Vázquez-Raygoza, Alejandra, Cano-González, Lucia, Velázquez-Martínez, Israel, Trejo-Soto, Pedro Josué, Castillo, Rafael, Hernández-Campos, Alicia, Hernández-Luis, Francisco, Oria-Hernández, Jesús, Castillo-Villanueva, Adriana, Avitia-Domínguez, Claudia, Sierra-Campos, Erick, Valdez-Solana, Mónica, Téllez-Valencia, Alfredo
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149853/
https://ncbi.nlm.nih.gov/pubmed/29186784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22122055
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