Species-Specific Inactivation of Triosephosphate Isomerase from Trypanosoma brucei: Kinetic and Molecular Dynamics Studies

Human African Trypanosomiasis (HAT), a disease that provokes 2184 new cases a year in Sub-Saharan Africa, is caused by Trypanosoma brucei. Current treatments are limited, highly toxic, and parasite strains resistant to them are emerging. Therefore, there is an urgency to find new drugs against HAT....

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Vázquez-Raygoza, Alejandra, Cano-González, Lucia, Velázquez-Martínez, Israel, Trejo-Soto, Pedro Josué, Castillo, Rafael, Hernández-Campos, Alicia, Hernández-Luis, Francisco, Oria-Hernández, Jesús, Castillo-Villanueva, Adriana, Avitia-Domínguez, Claudia, Sierra-Campos, Erick, Valdez-Solana, Mónica, Téllez-Valencia, Alfredo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149853/
https://ncbi.nlm.nih.gov/pubmed/29186784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22122055
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