Species-Specific Inactivation of Triosephosphate Isomerase from Trypanosoma brucei: Kinetic and Molecular Dynamics Studies

Human African Trypanosomiasis (HAT), a disease that provokes 2184 new cases a year in Sub-Saharan Africa, is caused by Trypanosoma brucei. Current treatments are limited, highly toxic, and parasite strains resistant to them are emerging. Therefore, there is an urgency to find new drugs against HAT....

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發表在:Molecules
Main Authors: Vázquez-Raygoza, Alejandra, Cano-González, Lucia, Velázquez-Martínez, Israel, Trejo-Soto, Pedro Josué, Castillo, Rafael, Hernández-Campos, Alicia, Hernández-Luis, Francisco, Oria-Hernández, Jesús, Castillo-Villanueva, Adriana, Avitia-Domínguez, Claudia, Sierra-Campos, Erick, Valdez-Solana, Mónica, Téllez-Valencia, Alfredo
格式: Artigo
語言:Inglês
出版: MDPI 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149853/
https://ncbi.nlm.nih.gov/pubmed/29186784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22122055
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