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Complex role of SIRT6 in NF-κB pathway regulation

The NF-κB pathway regulates cell physiology under stress conditions. We have recently described a novel NF-κB regulatory mechanism, by which SIRT6 induces cysteine monoubiquitination of the methyltransferase SUV39H1. This causes SUV39H1 dissociation from the gene encoding the NF-κB inhibitor IκBα,  ...

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Détails bibliographiques
Publié dans:Mol Cell Oncol
Auteurs principaux: Santos-Barriopedro, Irene, Vaquero, Alejandro
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149701/
https://ncbi.nlm.nih.gov/pubmed/30250909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2018.1445942
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