SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway

Sirtuins are NAD(+)-dependent deacetylases that facilitate cellular stress response. They include SirT6, which protects genome stability and regulates metabolic homeostasis through gene silencing, and whose loss induces an accelerated aging phenotype directly linked to hyperactivation of the NF-κB p...

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Yayımlandı:Nat Commun
Asıl Yazarlar: Santos-Barriopedro, Irene, Bosch-Presegué, Laia, Marazuela-Duque, Anna, de la Torre, Carolina, Colomer, Carlota, Vazquez, Berta N., Fuhrmann, Thomas, Martínez-Pastor, Bárbara, Lu, Wenfu, Braun, Thomas, Bober, Eva, Jenuwein, Thomas, Serrano, Lourdes, Esteller, Manel, Chen, Zhenbang, Barceló-Batllori, Silvia, Mostoslavsky, Raúl, Espinosa, Lluis, Vaquero, Alejandro
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760577/
https://ncbi.nlm.nih.gov/pubmed/29317652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02586-x
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