SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway

Sirtuins are NAD(+)-dependent deacetylases that facilitate cellular stress response. They include SirT6, which protects genome stability and regulates metabolic homeostasis through gene silencing, and whose loss induces an accelerated aging phenotype directly linked to hyperactivation of the NF-κB p...

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Pubblicato in:Nat Commun
Autori principali: Santos-Barriopedro, Irene, Bosch-Presegué, Laia, Marazuela-Duque, Anna, de la Torre, Carolina, Colomer, Carlota, Vazquez, Berta N., Fuhrmann, Thomas, Martínez-Pastor, Bárbara, Lu, Wenfu, Braun, Thomas, Bober, Eva, Jenuwein, Thomas, Serrano, Lourdes, Esteller, Manel, Chen, Zhenbang, Barceló-Batllori, Silvia, Mostoslavsky, Raúl, Espinosa, Lluis, Vaquero, Alejandro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760577/
https://ncbi.nlm.nih.gov/pubmed/29317652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02586-x
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