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Diastereoselective Spiroannulation of Phenolic Substrates: Advances Towards the Asymmetric Formation of the Manumycin m-C(7)N Core Skeleton

The asymmetric syntheses of two new spirolactones prepared in optically pure form from L-3-nitrotyrosine are described. The key step, an oxidative spiroannulation, was carried out on the optically active phenols 11a and 11b and afforded the new spirolactones 5a and 5b in 85% and 83% yields, respecti...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Plourde, Guy L., Spaetzel, Randy R., Kwasnitza, Jolene S., Scully, Thomas W.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149173/
https://ncbi.nlm.nih.gov/pubmed/17962738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/12092215
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