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Substrate Specificity of FUT8 and Chemoenzymatic Synthesis of Core-fucosylated Asymmetric N-glycans
Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for efficient synthesis of core-...
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| Publicado no: | Org Biomol Chem |
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| Principais autores: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4852481/ https://ncbi.nlm.nih.gov/pubmed/27080952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ob00586a |
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