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Substrate Specificity of FUT8 and Chemoenzymatic Synthesis of Core-fucosylated Asymmetric N-glycans

Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for efficient synthesis of core-...

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Détails bibliographiques
Publié dans:Org Biomol Chem
Auteurs principaux: Calderon, Angie D., Liu, Yunpeng, Li, Xu, Wang, Xuan, Chen, Xi, Li, Lei, Wang, Peng G.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852481/
https://ncbi.nlm.nih.gov/pubmed/27080952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ob00586a
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