Synthesis of a New Scaffold:the 7H,8H-Pyrimido[1,6-b]pyridazin-6,8-dione Nucleus

This paper describes a modified method of preparation of a number of α-aryl-α-(pyridazin-3-yl)-acetonitriles via the C-arylation reaction of the corresponding carbanions of phenylacetonitriles using 3-chloropyridazine derivatives. KOH and DMSO were used in the deprotonation process, which made the r...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Herold, Franciszek, Kałucka, Małgorzata, Król, Marek, Herold, Joanna, Kleps, Jerzy, Turło, Jadwiga
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149097/
https://ncbi.nlm.nih.gov/pubmed/18259149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/12122643
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