G-Quadruplex-Forming DNA Aptamers Inhibit the DNA-Binding Function of HupB and Mycobacterium tuberculosis Entry into Host Cells

The entry and survival of Mycobacterium tuberculosis (Mtb) within host cells is orchestrated partly by an essential histone-like protein HupB (Rv2986c). Despite being an essential drug target, the lack of structural information has impeded the development of inhibitors targeting the indispensable an...

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Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Kalra, Priya, Mishra, Subodh Kumar, Kaur, Surinder, Kumar, Amit, Prasad, Hanumanthappa Krishna, Sharma, Tarun Kumar, Tyagi, Jaya Sivaswami
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148841/
https://ncbi.nlm.nih.gov/pubmed/30245472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.08.011
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