Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells

BACKGROUND: We have previously reported an antigen-specific protocol to induce transplant tolerance and linked suppression to human embryonic stem cell (hESC)-derived tissues in immunocompetent mice through coreceptor and costimulation blockade. However, the exact mechanisms of acquired immune toler...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Genome Med
Egile Nagusiak: Leung, Cherry S., Yang, Kevin Y., Li, Xisheng, Chan, Vicken W., Ku, Manching, Waldmann, Herman, Hori, Shohei, Tsang, Jason C. H., Lo, Yuk Ming Dennis, Lui, Kathy O.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2018
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148788/
https://ncbi.nlm.nih.gov/pubmed/30236153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-018-0581-y
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