Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells

BACKGROUND: We have previously reported an antigen-specific protocol to induce transplant tolerance and linked suppression to human embryonic stem cell (hESC)-derived tissues in immunocompetent mice through coreceptor and costimulation blockade. However, the exact mechanisms of acquired immune toler...

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Bibliographic Details
Published in:Genome Med
Main Authors: Leung, Cherry S., Yang, Kevin Y., Li, Xisheng, Chan, Vicken W., Ku, Manching, Waldmann, Herman, Hori, Shohei, Tsang, Jason C. H., Lo, Yuk Ming Dennis, Lui, Kathy O.
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148788/
https://ncbi.nlm.nih.gov/pubmed/30236153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-018-0581-y
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