Preparation of 6-Substituted Quinoxaline JSP-1 Inhibitors by Microwave Accelerated Nucleophilic Substitution

A small library of 6-aminoquinoxalines has been prepared by nucleophilic substitution of 6-fluoroquinoxaline with amines and nitrogen-containing heterocycles under computer-controlled microwave irradiation. Some compounds were found to be potent inhibitors of JNK Stimulatory Phosphatase-1 (JSP-1) in...

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Veröffentlicht in:Molecules
Hauptverfasser: Zhang, Li, Qiu, Beiying, Li, Xin, Wang, Xin, Li, Jingya, Zhang, Yongliang, Liu, Jian, Li, Jia, Shen, Jingkang
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2006
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148675/
https://ncbi.nlm.nih.gov/pubmed/18007403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/11120988
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