Hydantoin Derivatives of l- and d-amino acids: Synthesis and Evaluation of Their Antiviral and Antitumoral Activity

3,5-Disubstituted hydantoin (1,3-imidazolidinedione) derivatives 5a-h were prepared by base induced cyclization of the corresponding N-(1-benzotriazolecarbonyl)-l- and d--amino acid amides 4a-h. Compounds 5a-h were evaluated for their cytostatic and antiviral activities. Among all the compounds eval...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Rajic, Zrinka, Zorc, Branka, Raic-Malic, Silvana, Ester, Katja, Kralj, Marijeta, Pavelic, Krešimir, Balzarini, Jan, De Clercq, Erik, Mintas, Mladen
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148488/
https://ncbi.nlm.nih.gov/pubmed/18007390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/11110837
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