Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency

Kidney proximal tubular cells (PTCs) are highly specialized for ultrafiltrate reabsorption and serve as paradigm of apical epithelial differentiation. Vps34/PI3-kinase type III (PI3KC3) regulates endosomal dynamics, macroautophagy and lysosomal function. However, its in vivo role in PTCs has not bee...

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Vydáno v:Sci Rep
Hlavní autoři: Grieco, Giuseppina, Janssens, Virginie, Gaide Chevronnay, Héloïse P., N’Kuli, Francisca, Van Der Smissen, Patrick, Wang, Tongsong, Shan, Jingdong, Vainio, Seppo, Bilanges, Benoit, Jouret, François, Vanhaesebroeck, Bart, Pierreux, Christophe E., Courtoy, Pierre J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148293/
https://ncbi.nlm.nih.gov/pubmed/30237523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32389-z
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