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Current understanding and dispute on the function of the Wnt signaling pathway effector TCF7L2 in hepatic gluconeogenesis

Approximately 10 years ago, the Wnt signaling pathway effector TCF7L2 (=TCF-4) was recognized as a type 2 diabetes (T2D) risk gene through a genome wide association study (GWAS). As the correlation between TCF7L2 polymorphisms and T2D susceptibility has been reproducibly observed by numerous follow-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Genes Dis
1. Verfasser: Jin, Tianru
Format: Artigo
Sprache:Inglês
Veröffentlicht: Chongqing Medical University 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147171/
https://ncbi.nlm.nih.gov/pubmed/30258876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gendis.2015.10.002
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