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PPARγ Deficiency Suppresses the Release of IL-1β and α in Macrophages via a Type 1 Interferon Dependent Mechanism

Obesity and diabetes modulate macrophage activation often leading to prolonged inflammation and dysfunctional tissue repair. Increasing evidence suggests that the NLRP3 inflammasome plays an important role in obesity-associated inflammation. We have previously shown that activation of the lipotoxic...

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Bibliografski detalji
Izdano u:J Immunol
Glavni autori: Weber, Kassandra J., Sauer, Madeline, He, Li, Tycksen, Eric, Kalugotla, Gowri, Razani, Babak, Schilling, Joel D.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147147/
https://ncbi.nlm.nih.gov/pubmed/30143592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800224
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