The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins

Type I interferon (IFN)-stimulated genes (ISGs) have critical roles in inhibiting virus replication and dissemination. Despite advances in understanding the molecular basis of ISG restriction, the antiviral mechanisms of many remain unclear. The 20-kDa ISG ISG20 is a nuclear 3′–5′ exonuclease with p...

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Detalhes bibliográficos
Publicado no:mSphere
Main Authors: Weiss, Christopher M., Trobaugh, Derek W., Sun, Chengqun, Lucas, Tiffany M., Diamond, Michael S., Ryman, Kate D., Klimstra, William B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147134/
https://ncbi.nlm.nih.gov/pubmed/30232164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00209-18
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