The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins

Type I interferon (IFN)-stimulated genes (ISGs) have critical roles in inhibiting virus replication and dissemination. Despite advances in understanding the molecular basis of ISG restriction, the antiviral mechanisms of many remain unclear. The 20-kDa ISG ISG20 is a nuclear 3′–5′ exonuclease with p...

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Publicat a:mSphere
Autors principals: Weiss, Christopher M., Trobaugh, Derek W., Sun, Chengqun, Lucas, Tiffany M., Diamond, Michael S., Ryman, Kate D., Klimstra, William B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147134/
https://ncbi.nlm.nih.gov/pubmed/30232164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00209-18
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