Marked Global DNA Hypomethylation Is Associated with Constitutive PD-L1 Expression in Melanoma

Constitutive expression of the immune checkpoint, PD-L1, inhibits anti-tumor immune responses in cancer, although the factors involved in PD-L1 regulation are poorly understood. Here we show that loss of global DNA methylation, particularly in intergenic regions and repeat elements, is associated wi...

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Publicado no:iScience
Main Authors: Chatterjee, Aniruddha, Rodger, Euan J., Ahn, Antonio, Stockwell, Peter A., Parry, Matthew, Motwani, Jyoti, Gallagher, Stuart J., Shklovskaya, Elena, Tiffen, Jessamy, Eccles, Michael R., Hersey, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147024/
https://ncbi.nlm.nih.gov/pubmed/30240750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.05.021
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