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Asymmetric Synthesis of (R)‐1‐Alkyl‐Substituted Tetrahydro‐ß‐carbolines Catalyzed by Strictosidine Synthases

Stereoselective methods for the synthesis of tetrahydro‐ß‐carbolines are of significant interest due to the broad spectrum of biological activity of the target molecules. In the plant kingdom, strictosidine synthases catalyze the C−C coupling through a Pictet–Spengler reaction of tryptamine and seco...

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Dettagli Bibliografici
Pubblicato in:Angew Chem Int Ed Engl
Autori principali: Pressnitz, Desiree, Fischereder, Eva‐Maria, Pletz, Jakob, Kofler, Christina, Hammerer, Lucas, Hiebler, Katharina, Lechner, Horst, Richter, Nina, Eger, Elisabeth, Kroutil, Wolfgang
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146909/
https://ncbi.nlm.nih.gov/pubmed/29852524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201803372
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