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Ribosomal RACK1:Protein Kinase C βII Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation

Eukaryotic ribosomes contain the high-affinity protein kinase C βII (PKCβII) scaffold, receptor for activated C kinase (RACK1), but its role in protein synthesis control remains unclear. We found that RACK1:PKCβII phosphorylates eukaryotic initiation factor 4G1 (eIF4G1) at S1093 and eIF3a at S1364....

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Dobrikov, Mikhail I., Dobrikova, Elena Y., Gromeier, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146833/
https://ncbi.nlm.nih.gov/pubmed/30012863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00304-18
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