Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus

A third of humans carry genetic variants of the ITP pyrophosphatase (ITPase) gene (ITPA) that lead to reduced enzyme activity. Reduced ITPase activity was earlier reported to protect against ribavirin-induced hemolytic anemia and to diminish relapse following ribavirin and interferon therapy for hep...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Nyström, Kristina, Wanrooij, Paulina H., Waldenström, Jesper, Adamek, Ludmila, Brunet, Sofia, Said, Joanna, Nilsson, Staffan, Wind-Rotolo, Megan, Hellstrand, Kristoffer, Norder, Helene, Tang, Ka-Wei, Lagging, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146798/
https://ncbi.nlm.nih.gov/pubmed/30045981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01087-18
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