HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways

BACKGROUND: Cartilage oligomeric matrix protein (COMP) is known to promote fibrosis in skin, lung and liver. Emerging evidence shows that COMP plays critical roles in tumor development, including breast cancer, colon cancer and hepatocellular carcinoma (HCC). Nevertheless, the role of COMP in HCC pr...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Li, Qing, Wang, Cong, Wang, Yufeng, Sun, Liankang, Liu, Zhikui, Wang, Liang, Song, Tao, Yao, Yingmin, Liu, Qingguang, Tu, Kangsheng
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146743/
https://ncbi.nlm.nih.gov/pubmed/30231922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0908-y
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