Resolvin D1 prevents epithelial-mesenchymal transition and reduces the stemness features of hepatocellular carcinoma by inhibiting paracrine of cancer-associated fibroblast-derived COMP

BACKGROUND: Cancer stem cells (CSCs) require stromal signals for maintaining pluripotency and self-renewal capacities to confer tumor metastasis. Resolvin D1 (RvD1), an endogenous anti-inflammatory lipid mediator, has recently been identified to display anti-cancer effects by acting on stroma cells....

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Bibliographic Details
Published in:J Exp Clin Cancer Res
Main Authors: Sun, Liankang, Wang, Yufeng, Wang, Liang, Yao, Bowen, Chen, Tianxiang, Li, Qing, Liu, Zhikui, Liu, Runkun, Niu, Yongshen, Song, Tao, Liu, Qingguang, Tu, Kangsheng
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472102/
https://ncbi.nlm.nih.gov/pubmed/30999932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1163-6
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