Simvastatin reduces TGF-β1-induced SMAD2/3-dependent human ventricular fibroblasts differentiation: role of protein phosphatase activation

BACKGROUND: Excessive cardiac fibrosis due to maladaptive remodeling leads to progression of cardiac dysfunction and is modulated by TGF-β1-activated intracellular phospho-SMAD signaling effectors and transcription regulators. SMAD2/3 phosphorylation, regulated by protein-phosphatases, has been stud...

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Publicado en:Int J Cardiol
Main Authors: Rizvi, Farhan, Siddiqui, Ramail, DeFranco, Alessandra, Homar, Peter, Emelyanova, Larisa, Holmuhamedov, Ekhson, Ross, Gracious, Tajik, A. Jamil, Jahangir, Arshad
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146406/
https://ncbi.nlm.nih.gov/pubmed/30220377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcard.2018.06.061
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