Rhubarb Protect Against Tubulointerstitial Fibrosis by Inhibiting TGF-β/Smad Pathway and Improving Abnormal Metabolome in Chronic Kidney Disease

Tubulointerstitial fibrosis is the final common pathway for all kidney diseases leading to chronic kidney disease (CKD). TGF-β/Smad signaling pathway plays a key role in renal fibrosis. Previous studies have revealed that rhubarb extracts attenuated the increase of transforming growth factor-β 1 (TG...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Zhang, Zhi-Hao, Li, Ming-Hua, Liu, Dan, Chen, Hua, Chen, Dan-Qian, Tan, Ning-Hua, Ma, Shuang-Cheng, Zhao, Ying-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146043/
https://ncbi.nlm.nih.gov/pubmed/30271345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01029
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