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A novel λ integrase-mediated seamless vector transgenesis platform for therapeutic protein expression

Advances in stem cell engineering, gene therapy and molecular medicine often involve genome engineering at a cellular level. However, functionally large or multi transgene cassette insertion into the human genome still remains a challenge. Current practices such as random transgene integration or ta...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Makhija, Harshyaa, Roy, Suki, Hoon, Shawn, Ghadessy, Farid John, Wong, Desmond, Jaiswal, Rahul, Campana, Dario, Dröge, Peter
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144826/
https://ncbi.nlm.nih.gov/pubmed/29893931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky500
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