Germline DNA replication timing shapes mammalian genome composition

Mammalian DNA replication is a highly organized and regulated process. Large, Mb-sized regions are replicated at defined times along S-phase. Replication Timing (RT) is thought to play a role in shaping the mammalian genome by affecting mutation rates. Previous analyses relied on somatic RT profiles...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Yehuda, Yishai, Blumenfeld, Britny, Mayorek, Nina, Makedonski, Kirill, Vardi, Oriya, Cohen-Daniel, Leonor, Mansour, Yousef, Baror-Sebban, Shulamit, Masika, Hagit, Farago, Marganit, Berger, Michael, Carmi, Shai, Buganim, Yosef, Koren, Amnon, Simon, Itamar
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144785/
https://ncbi.nlm.nih.gov/pubmed/29986092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky610
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