Flupirtine derivatives as potential treatment for the neuronal ceroid lipofuscinoses

OBJECTIVE: Neuronal Ceroid Lipofuscinoses (NCL) are fatal inherited neurodegenerative diseases with established neuronal cell death and increased ceramide levels in brain, hence, a need for disease‐modifying drug candidates, with potential to enhance growth, reduce apoptosis and lower ceramide in ne...

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Vydáno v:Ann Clin Transl Neurol
Hlavní autoři: Makoukji, Joelle, Saadeh, Fadi, Mansour, Karl Albert, El‐Sitt, Sally, Al Ali, Jamal, Kinarivala, Nihar, Trippier, Paul C., Boustany, Rose‐Mary
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144451/
https://ncbi.nlm.nih.gov/pubmed/30250865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.625
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